A Phase 3 research study  ·  conducted at academic and community research sites across the United States  ·  NCT07717411
Sponsored research in collaboration with Roche Antidote

Could protecting brain health start before memory loss does?

PrevenTRON is studying whether an investigational treatment can help protect brain health in adults who show early biological signs of Alzheimer's risk, before symptoms appear.

Participation is voluntary. Ask questions, take your time, and leave the study at any point.
Illustration representing early memory concerns associated with Alzheimer's risk
Trial at a glance
StatusEnrolling
PhasePhase III
FocusAlzheimer's Prevention
Ages60–80
DurationMulti-year, visit-based
VisitsOutpatient, no overnight stay
LocationsMultiple sites, nationwide
Cost$0 – Travel & time reimbursed
Eligibility

Who this study is looking for

This is meant as a general guide. The study team confirms eligibility with you directly, at no cost or commitment.

You may be eligible if you:

  • ✓Are between 60 and 80 years old
  • ✓Have no current diagnosis of Alzheimer's disease or dementia
  • ✓Have not noticed significant changes in memory or daily functioning
  • ✓Are willing to complete a brain scan or blood test to check for early risk markers
  • ✓Live within reasonable travel distance of a participating research site, or are open to a site that offers remote visits

You don't need a family history of Alzheimer's to join. Many people who qualify have none at all. Early risk comes from biological testing, separate from family background.

Current recruiting studies

Research currently enrolling at participating sites

PrevenTRON is one of several studies open at our participating research sites. Here's what's currently recruiting.

Observational

The Memory & Aging Registry

Multiple sites · Nationwide
  • Adults 55 and older, any memory status
  • Tracking only (no investigational treatment)
  • Helps match participants to future studies like PrevenTRON
Why this research matters

Why researchers are starting earlier, before symptoms appear

Alzheimer's disease develops gradually, often beginning years before any memory symptoms are noticeable. By the time a diagnosis is made, significant changes may have already taken place in the brain.

This is why a growing part of Alzheimer's research, including PrevenTRON, is focused on identifying early biological risk and studying whether acting sooner can change the course of the disease before symptoms ever appear.

Research also suggests that a meaningful share of dementia risk is tied to factors that can potentially be addressed, which is part of why prevention-focused studies matter alongside lifestyle and public health efforts.

55M+people are living with dementia worldwide today.
Every 3sa new case of dementia is estimated to arise somewhere in the world.
~40%of dementia cases globally are linked to factors researchers believe may be modifiable.
10 yrsbuilding cognitive reserve may delay symptom onset by up to a decade in some research.
How the study works

Why researchers are looking before symptoms start

Alzheimer's-related changes in the brain can begin years, sometimes decades, before memory problems appear. PrevenTRON is studying whether treating the earliest biological signs can help protect brain health well before symptoms would otherwise appear.

01 – THE QUESTION

What causes early risk

A protein called amyloid can build up in the brain long before any memory changes are noticeable. Researchers believe this early buildup may be part of what eventually leads to Alzheimer's disease.

02 – THE APPROACH

What PrevenTRON is testing

The study is testing whether an investigational medication can reduce this early buildup in people who are at biological risk but do not yet have memory symptoms, with the goal of delaying or preventing decline.

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Have a question about whether PrevenTRON could be right for you? Call anytime. There's no obligation.

Before you decide

How clinical trials work

Before a medicine is studied in people, it has already gone through years of laboratory and pre-clinical research.

01

Safety testing is completed in the lab before human trials begin.

02

Regulatory authorities like the FDA review the data before a study can proceed.

03

An independent ethics committee (IRB) approves the study protocol.

04

Human trials confirm how the treatment behaves in the body under close monitoring.

05

Studies are carefully structured and conducted under ongoing regulatory oversight.

Global impact

Why this research reaches beyond any one participant

For many participants, being part of a study like PrevenTRON means contributing to research that may benefit people well beyond their own community.

55M+

people living with dementia worldwide today

139M

people projected to be living with dementia by 2050

60–70%

of dementia cases are caused by Alzheimer's disease specifically

~10M

new dementia cases are diagnosed worldwide each year

Figures reflect widely cited estimates from the World Health Organization and Alzheimer's Disease International; global dementia research is ongoing and estimates continue to be refined.

Questions people ask

Common questions about participating

Every treatment in this study has already gone through earlier phases of testing before reaching this stage. Like all investigational treatments, it may carry risks that are still being studied, and the study team will review all known side effects with you in detail before you decide whether to participate.
This depends on the specific study protocol at your site, and the study team will explain this clearly during the screening visit, before any testing happens. You're welcome to ask this question as early in the process as you'd like.
Time commitment varies by study site and phase, and typically involves periodic visits over an extended period. The study team will walk through the full visit schedule with you before you decide, so you can weigh it against your own schedule.
Yes. You can stop participating at any time, for any reason, without it affecting your regular medical care. This is a standard right in all research studies and will be part of the consent conversation.
Not qualifying for this particular study doesn't reflect your health status negatively, and the study team can often point you toward other research or resources that may be a better fit.

Ready to have a no-pressure conversation?

Reaching out doesn't commit you to anything. It's simply a chance to ask questions and find out whether PrevenTRON might be a fit.

There's no cost and no obligation. The decision is yours at every step.